Feb 1, 2019 · Our study shows that expression of DNA repair enzymes, such as PARP1, BRCA1 and XRCC1, are activated during macrophage development by the SWI/SNF chromatin remodelling complex, which serves as a histone acetylation sensor. It recognises and displaces epigenetically marked nucleosomes, thereby enabling transcription.

CREB-binding protein (CREBBP) and E1A-binding protein P300 (EP300) are two key acetyltransferases and transcriptional cofactors that regulate gene expression by regulating the acetylation levels of histone proteins and non-histone proteins.

Oct 10, 2022 · We show that CBP/p300 and HDAC activities play important roles in regulating H3K27ac dynamics and are essential for preimplantation development. Specifically, CBP/p300 acetyltransferase broadly deposits H3K27ac in zygotes to induce the opening of condensed chromatin at putative enhancers and ensure proper ZGA.

May 20, 2019 · However, in the nucleus of human IPF fibroblasts (Fig. 9b), we detected both increase of active EP300, which inactivates HDAC1 and disrupts HDAC1-C1D interaction, and reduced levels of MIRLET7D, which compromises MiCEE-mediated epigenetic gene silencing.

May 31, 2021 · Accordingly, EP300/P300 sequesters LC3 in the nucleus under nutrient-rich conditions, while deacetylation of LC3, catalyzed by the deacetylase SIRT1, results in nucleo-cytoplasmic translocation...

Our studies suggest that acetylation of Api5 at lysine 251 is mediated by p300 histone acetyltransferase while de-acetylation is carried out by HDAC1. Inhibition of acetylation by p300 leads to a reduction in Api5 levels while inhibition of deacetylation by …

Our study shows that expression of DNA repair enzymes, such as PARP1, BRCA1 and XRCC1, are activated during macrophage development by the SWI/SNF chromatin remodelling complex, which serves as a histone acetylation sensor. It recognises and displaces epigenetically marked nucleosomes, thereby enabling transcription.

Feb 1, 2019 · Our study shows that expression of DNA repair enzymes, such as PARP1, BRCA1 and XRCC1, are activated during macrophage development by the SWI/SNF chromatin remodelling complex, which serves as a histone acetylation sensor. It recognises and displaces epigenetically marked nucleosomes, thereby enabling transcription.

Rubio and colleagues [102] demonstrated that in the nuclei of IPF patients, EP300 hyperactivity inhibits nuclear HDAC1 and impairs the functionality of MiCEE, a ribonucleoprotein complex that...

Aug 12, 2021 · Our studies suggest that acetylation of Api5 at lysine 251 is mediated by p300 histone acetyltransferase while de-acetylation is carried out by HDAC1. Inhibition of acetylation by p300 leads to a...