The Epigenetic Regulator HDAC1 Modulates Transcription of a …
CMCs depleted of HDAC1 exhibited induction of a cardiogenic transcriptional program characterized by enhanced expression of cardiomyogenic (MEF2C, NKX2.5, and TBX5)- and …
The histone deacetylase HDAC1 activates HIF1α/VEGFA
Sep 5, 2020 · Our study revealed that Histone Deacetylase 1 (HDAC1) directly inhibits the ubiquitination of HIF1α. Additionally, HDAC1 activates HIF1α/VEGFA signaling pathway, …
The histone deacetylase HDAC1 controls dendritic cell ... - Cell Press
Multi-omics analyses reveal that HDAC1 controls expression, chromatin accessibility, and histone acetylation of the transcription factors IRF4, IRF8, and SPIB required for efficient development …
Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 …
Apr 1, 2023 · Rutin could alleviate EndMT and restore autophagy in vivo and in vitro models. Proteomics analysis results showed that HDAC1 significantly downregulated in the 200 …
The histone deacetylase HDAC1 controls dendritic cell ... - PubMed
Jun 25, 2024 · Here, we investigate the impact of histone deacetylation on DCs by genetically deleting histone deacetylase 1 (HDAC1) or HDAC2 in hematopoietic progenitors and CD11c …
BIN2 inhibition suppress ovarian cancer progression meanwhile …
We found that although both HDAC1i and iBPP significantly decreased OC growth (Figure 4A and B), shown as decreased p‐HDAC1 and increased H3K27ac in ovaries (Figure 4C–E) and …
HDAC1 and 2 regulate endothelial VCAM-1 expression and …
This study investigated whether and how the clinically available histone deacetylases 1 and 2 (HDAC1/2) inhibitor drug Romidepsin epigenetically modulates VCAM-1 expression to …
HDAC Inhibitors Alleviate Uric Acid–Induced Vascular Endothe ... - LWW
Mocetinostat, an isoform-selective HDAC inhibitor, which specifically inhibits HDAC1, HDAC2, and HDAC3, was used to evaluate whether HDAC1-3 can mediate the protective effect of TSA.
Epigenetic Regulator HDAC1 Modulates Transcription of a Core ...
Sep 1, 2016 · CMCs depleted of HDAC1 exhibited induction of a cardiogenic transcriptional program characterized by enhanced expression of cardiomyogenic (MEF2C, NKX2.5, and …
Histone Deacetylases 1 and 2 Regulate Microglia Function during ...
Mar 20, 2018 · Datta et al. show that histone deacetylases Hdac1 and Hdac2 are essential for microglial survival and expansion during development but not during steady state. In …