Histone Deacetylases (HDACs): Evolution, Specificity, Role in ...
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences …
Histone deacetylase - Wikipedia
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH 3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. [2] …
The role of histone deacetylases (HDACs) in human cancer
Acetylation levels are the result of the balance of the activities of histone acetyltransferase (HAT) and histone deacetylase (HDAC). The levels of histone acetylation play a crucial role in …
The many roles of histone deacetylases in development and physiology ...
Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful …
Histone deacetylase complexes: Structure, regulation and function
Sep 1, 2024 · HDAC complexes play vital roles in the regulation of key biological processes such as transcription, replication, and DNA repair. Moreover, deregulated HDAC complex function is …
Histone Deacetylase - an overview | ScienceDirect Topics
Histone deacetylases (HDACs) are a group of enzymes that remove acetyl groups from histones, resulting in chromatin condensation and transcriptional repression. They also regulate the …
The many roles of histone deacetylases in development and
Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful …
Role of HDACs in normal and malignant hematopoiesis
Jan 7, 2020 · Histone deacetylases (HDACs) are a series of key transcriptional cofactors that regulate gene expression by deacetylation of lysine residues on histone and nonhistone …
The role of HDAC3 and its inhibitors in regulation of oxidative …
Apr 18, 2023 · HDAC3 is critical for early embryonic growth, development of vital organs, and numerous metabolic processes. HDAC3 is closely correlated to mitochondria function and …
HDAC4: mechanism of regulation and biological functions
HDACs are divided into three distinct classes: I, II, and III, on the basis of size and sequence homology, as well as formation of distinct complexes. Among class II HDACs, HDAC4 is …