Precision Targeting with EZH2 and HDAC Inhibitors in ... - PubMed
Sep 1, 2019 · Inhibition of EZH2 and HDAC is synergistic and leads to the dissociation of PRC2 complex. Our findings support the clinical translation of the combination of EZH2 and HDAC …
Discovery of epigenetic modulators targeting HDACs and EZH2 ...
Dec 1, 2024 · Satisfyingly, compounds 22a and 22b were identified as potent HDACs/EZH2 dual inhibitors with robust antiproliferative activities against one diffuse large-cell B cell lymphomas …
Dual Targeting of EZH2 and HDAC with Tazemetostat and …
Nov 5, 2021 · Here, we utilize transcriptomic and flow cytometric methods to assess whether epigenetic remodeling with tazemetostat (EZH2 inhibitor) and belinostat (HDAC inhibitor) can …
Epigenetic Targeting with EZH2 and HDAC Inhibitors Is Synergistic …
Dec 2, 2016 · This data suggests that concomitant inhibition of EZH2 and HDAC is highly synergistic and leads to the dissociation of PRC2 complex. By releasing transcriptional …
Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical …
Since the histone modifying enzymes EZH2 and HDACs control a number of epigenetic-dependent carcinogenic pathways, we designed the first-in-class dual EZH2/HDAC inhibitor 5 …
Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage
Feb 27, 2024 · We show that hypoxia-activated XBP1s forms a stable repressor protein complex with HDAC2 and EZH2 to suppress ΔNp63α transcription. Notably, H3K27ac is predominantly …
Precision Targeting with EZH2 and HDAC Inhibitors in …
Sep 3, 2019 · Inhibition of EZH2 and HDAC is synergistic and leads to the dissociation of PRC2 complex. Our findings support the clinical translation of the combination of EZH2 and HDAC …
The Synergistic Anti-Tumor Activity of EZH2 Inhibitor SHR2554 and HDAC …
Aug 24, 2021 · The combination of HDAC inhibitor HBI8000 with EZH2 inhibitor SHR2554 exhibited dramatic anti-tumor activity in both mutant and wild-type DLBCL, which may become …
Dual Targeting of EZH2 and HDAC with Tazemetostat and …
Nov 23, 2021 · Here, we utilize transcriptomic and flow cytometric methods to assess whether epigenetic remodeling with tazemetostat (EZH2 inhibitor) and belinostat (HDAC inhibitor) can …
Recent advances in EZH2-based dual inhibitors in the treatment of ...
Aug 5, 2023 · EZH2 cooperates with HDAC in reprogramming histone acetylation and methylation, resulting in more permanent silencing of target genes. HDAC2 interacts with …