Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH 3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. [2] HDACs allow histones to wrap the DNA more tightly. [3]

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles.

Histone deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis, and cell cycle arrest in cancer cells.

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises ...

Histone deacetylases (HDACs) are a group of enzymes that remove acetyl groups from histones, resulting in chromatin condensation and transcriptional repression. They also regulate the acetylation status of non-histone proteins and cytoplasmic proteins. Inhibiting HDACs can lead to hyper-acetylated histones, cell cycle arrest, and cell death.

Aug 18, 2014 · Epigenetic deregulation can underpin the onset and progression of several human diseases. The expression and/or function of histone deacetylases (HDACs) is often perturbed in cancer,...

Feb 27, 2007 · Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two counteracting enzyme families whose enzymatic activity controls the acetylation state of protein lysine residues,...

Histone deacetylase (HDAC) is a major class of deacetylation enzymes. HDAC catalyzes the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. Many HDACs exist in large protein complexes in cells and their functions strongly depend on the complex composition.

Histone acetylation and deacetylation are essential parts of gene regulation. These reactions are typically catalysed by enzymes with "histone acetyltransferase" (HAT) or "histone deacetylase" (HDAC) activity. Acetylation is the process where an acetyl functional group is transferred from one molecule (in this case, acetyl coenzyme A) to another.

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. In humans, there are 18 HDAC enzymes that use either zinc- or NAD + -dependent mechanisms to …