H69 was selected to represent the lower quartile of DLL3 -positive SCLC cell lines in order to challenge the sensitivity limits of DLL3 immunoPET imaging. In vitro cell binding assays using …

Jul 13, 2017 · Two cell lines, H82 (representing the median of DLL3 expression) and H69 (low DLL3 expression < 25th percentile), were selected for the development of in vitro and in vivo …

May 20, 2019 · In this study, the expression of DLL3 was analyzed using different DLL3 antibodies in high-grade neuroendocrine tumors of the lung and cell cultures. Additionally, …

May 1, 2016 · An exploration of the microarray gene expression data from the cancer cell line encyclopedia followed by immunohistochemistry on various SCLC cell lines identified NCI H82 …

Mar 12, 2025 · A Fluorescence microscopy of co-cultures of DLL3-positive GFP-expressing SCLC cell lines (GFP-SHP-77 and GFP-H69) with circRNA-based anti-DLL3 CAR-T cells at various …

Mar 15, 2019 · To investigate the functional role of DLL3 in SCLC, H69, H82, MS-1 and H592 cells that showed DLL3 expression were transfected with DLL3 -siRNA followed by …

Jun 2, 2020 · Similarly, H69 cell line could be considered a “critical sample” for preanalytical conditions testing and their influence on DLL3 IHC. Differences between the conditions were …

Delta-like protein 3 (DLL3) is expressed specifically in SCLC and is considered a promising therapeutic target for patients with this disease. Rovalpituzumab tesirine (Rova-T) was the first...

Mar 22, 2023 · Delta-like protein 3 (DLL3) has been identified as a tumor-specific cell surface marker on neuroendocrine cancers including SCLC. In this study, we developed a chimeric …

DLL3 acts as an inhibitory ligand that downregulates Notch signaling and is upregulated by ASCL1, a transcription factor prevalent in the small-cell lung cancer (SCLC) subtype SCLC-A. …