In this Perspective, we provide an overview of currently available mouse models of acute and chronic GvHD, highlighting their benefits and limitations, and discuss research and clinical opportunities for the future.

Jun 7, 2024 · Graft-versus-host disease (GVHD) is a systemic disorder occurring when immune cells from transplanted tissue recognize the recipient's body as foreign and attack its cells. In this context, graft refers to transplanted or donated tissue, while host refers to the recipient's tissues.

This study shows that CD4 + T cells can mediate GVHD in MHC-mismatched transplants without contacting recipient non-haematopoietic tissues.

A complete understanding of the HLA barrier in graft-versus-host disease (GVHD) after unrelated donor HCT requires an appreciation of the unique features of the classical HLA genes, non-HLA loci resident to the human MHC, and the constituents of extended MHC haplotypes.

GVHD is a major complication in allogeneic bone marrow transplantation (BMT). MHC class I mismatching increases GVHD, but in MHC-matched BMT minor histocompatibility antigens (mH) presented by MHC class I result in significant GVHD.

Sep 12, 2013 · Recent information on the major histocompatibility complex (MHC) region of chromosome 6 as an important source of untyped genetic variation has shed light on novel GVHD determinants. These data open new paradigms for understanding the genetic basis of GVHD.

Nov 10, 2018 · We examined over an extended time period 7 MHC-matched, minor antigen–mismatched mouse models for development of cGVHD. Development and manifestations of cGVHD were determined by a combination of MHC allele type and recipient strain, with BALB recipients being the most susceptible.

3 days ago · Graft-versus-Host Disease (GvHD) is the main cause of morbidity and mortality of allogeneic hematopoietic cell transplantation (allo-HCT). ... (i.e the non-classical MHC-I molecule HLA-G).

Sep 26, 2019 · Aiming for a higher translational value, we constructed an MHC major mismatched [C57BL/6 (H-2 Kb) to BALB/c (H-2Kd)] aGVHD mouse model based on busulfan/cyclophosphomide (BU–CY) conditioning and...

MHC class II antigen presentation by ileal epithelial cells, upregulated following IL-12- and microbiota-dependent IFN-γ production by host hematopoietic cells, is critical for the initiation of intestinal GVHD.