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Jul 1, 2011 · An element known as a GU-rich element (GRE) with a similar sequence pattern to the ARE was discovered in a subset of unstable transcripts in human T-cells and was shown to destabilize the mRNA. 9 The core pentamer of a GRE is GUUUG, and the minimal consensus found in the labile mRNA group is UGUUUGUUUGU. 9 GREs are also targets for at least one ...

GREs have similar sequence clustering patterns with AREs such as overlapping GUUUG pentamers and enrichment in 3'UTRs. Functional analysis using T-cell mRNA expression microarray data confirms correlation with mRNA destabilization.

Four secondary motifs (GCUUG, GAAUG, GUUUG, GUAUG) are indicated among the top 200 highly enriched 5 mers derived from intronic HiTS-CLIP peaks from mouse ventral spinal neurons.

RNA interference (RNAi) technology has been used to elucidate gene function, to generate model systems and to identify new molecular targets. In addition, RNAi is currently progressing from basic research to potential therapeutic applications.

Presumably, the vast majority of 7-mer transcripts synthesized at 50 μM UTP were the result of simple abortive initiation. These results indicate that CTP is required to extend the GUUUG transcript and that the aborted 7-mer is not extended in the absence of ATP.

Jul 1, 2011 · GREs have similar sequence clustering patterns with AREs such as overlapping GUUUG pentamers and enrichment in 3'UTRs. Functional analysis using T-cell mRNA expression microarray data confirms...

Nov 23, 2015 · The search for more sequence patterns and parsing of the whole gene body leads to an increase in predicted motifs. Table 2 shows a comparison of genes per genome containing at least one core ARE (AUUUA), GRE (GUUUG) and URE (UUUUU).

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