Eukaryotic peptide chain release factor GTP-binding subunit ERF3A is an enzyme that in humans is encoded by the GSPT1 gene. [5][6][7]

Mar 30, 2025 · Complete information for GSPT1 gene (Protein Coding), G1 To S Phase Transition 1, including: function, proteins, disorders, pathways, orthologs, and expression.

Aug 20, 2021 · GSPT1 (G1 to S phase transition 1) is a translation termination factor that recognizes the termination codon by binding eRF1, forcing the proteins to dissociate from the …

Feb 1, 2024 · Molecular glue targeting GSPT1 is an innovative antitumor agent, which induces degradation of GSPT1 and affects proliferation, migration, and invasion of various tumor cells.

Aug 8, 2024 · We previously reported that G1 to S phase transition 1 (GSPT1) depletion induces delayed cell cycle in primary astrocytes. Herein, we examined the potential of GSPT1 as a …

We identified the domains of GSPT1 essential for cell survival and show that GSPT1 degradation leads to impaired translation termination, activation of the integrated stress response pathway, …

Studied demonstrated that GSPT1 plays a vital role in the acute myeloid leukemia (AML) and MYC-driven lung cancer. Thus, molecular glue (MG) degraders targeting GSPT1 is a novel …

Identification of GSPT1 as prognostic biomarker and promoter of malignant colon cancer cell phenotypes via the GSK-3beta/CyclinD1 pathway. miR-27b-3p suppresses gastric cancer cell …

Jun 22, 2016 · We identified GSPT1 (eRF3a) as a novel CC-885-dependent cereblon substrate mediating the anti-proliferative effects of CC-885. GSPT1 is a translation termination factor …

To determine if our GSPT1 degraders induce similar ternary complex formation, we employed AlphaScreen technology to measure luminescence arising from the proximity of CRBN/DDB1 …