Furthermore, we show that GR acts both as a direct inhibitor of CREB binding protein (CBP)-associated HAT activity and also by recruiting HDAC2 to the p65-CBP HAT complex. This …

Mar 5, 2019 · We identified the glucocorticoid receptor (GR) as being responsible for that downregulation, and suggested a correlation between GR and HDAC2 inhibition after VPA …

Oct 1, 2019 · Glucocorticoid receptor-α (GR-α) and histone deacetylase 2 (HDAC2) play critical roles in the sensitivity to corticosteroid therapy; however, it is unclear whether HDAC2 and/or …

Oct 10, 2006 · Brg1 is critical for formation of stable in vivo complexes between GR and NGFI-B, and between GR and HDAC2. Promoter recruitment of both GR and HDAC2 are Gc- …

Jan 23, 2006 · We show that a defect of glucocorticoid receptor (GR) deacetylation caused by impaired histone deacetylase (HDAC) 2 induces glucocorticoid insensitivity toward nuclear …

Oct 17, 2011 · This corticosteroid resistance is largely caused by inactivation of histone deacetylase 2 (HDAC2), which is critical for the transrepressive activity of the glucocorticoid …

Jul 3, 2024 · Histone deacetylases (HDACs) and glucocorticoid receptor (GR) signaling are critical in regulating gene expression and stress responses. Vorinostat, an HDAC inhibitor, shows …

Immunofluorescence showed nuclear colocalization of GR and histone deacetylase–2 (HDAC2) in MUC5AC -expressing NHBE cells. ChIP also showed a rapid temporal recruitment of HDAC2 …

Dec 9, 2014 · Treating hippocampal neurons with cellular stressors such as hydrogen peroxide or Aβ induces the activation of GR, binding of GR to the HDAC2 promoter, and HDAC2 expression.

Jun 1, 2020 · Highlights • Prenatal caffeine exposure (PCE) caused osteoarthritis susceptibility in offspring. • The low-expressional TGFβR1 contributed to the inhibited cartilage matrix …