GIPC is an acronym for "GAIP Interacting Protein C-terminus". RGS proteins are "Regulators of G protein Signaling" and RGS-GAIP is a "GTPase Activator protein for Gαi/Gαq", which are two major subtypes of Gα proteins.

Mar 30, 2025 · GIPC1 (GIPC PDZ Domain Containing Family Member 1) is a Protein Coding gene. Diseases associated with GIPC1 include Oculopharyngodistal Myopathy 2 and Oculopharyngodistal Myopathy 1. Among its related pathways are Negative regulation of FGFR3 signaling and Signaling by TGFBR3.

Feb 8, 2025 · GIPC1 is a novel breast cancer-associated immunogenic antigen that is overexpressed in breast cancer; GIPC1 protein is overexpressed in ovarian and breast cancer; Targeting GIPC could be a promising new treatment option for pancreatic cancer. Observational study of gene-disease association. (HuGE Navigator)

Jun 4, 2020 · To investigate the distribution of GIPC1 protein in muscle fibers derived from OPDM-affected individuals with GGC repeat expansions in the 5′ UTR of GIPC1, immunofluorescence was carried out in two GIPC1-affected individuals (S6, S7) and an age-matched control.

GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human malignancies, including breast, ovarian, gastric, and …

Gene Ontology (GO) annotations organized by slimming set. The disease may be caused by variants affecting the gene represented in this entry. GGC repeat expansions in the 5'-UTR ranging from 73 to 164 were reported in patients, compared with a normal range from 12 to 32 in unaffected individuals.

GIPC1 expression was elevated in GC tissues, liver metastasis tissues, and lymph node metastases. GIPC1 knockdown or GIPC1 blocking peptide blocked the platelet-derived growth factor receptor (PDGFR)/PI3K/AKT signaling pathway, and inhibited the proliferation and migration of GC cells.

Dec 28, 2023 · This study aimed to investigate whether GAIP interacting protein, C terminus 1 (GIPC1) represents a therapeutic target and its regulating mechanism in GC. GIPC1 expression was elevated in GC tissues, liver metastasis tissues, and lymph node metastases.

Dec 10, 2024 · GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009] Expression Broad expression in colon (RPKM 53.4), esophagus (RPKM 31.8) and 23 other tissues See more

Here, we identified a novel SR-B1-interacting protein, GIPC1 (GAIP-interacting protein, C terminus 1) that interacts with SR-B1 and stabilizes SR-B1 by negative regulation of its proteasomal and lysosomal degradation pathways.