Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. [3][4] It belongs to the dynamin superfamily of large GTPases.

Mar 30, 2025 · Complete information for GBP1 gene (Protein Coding), Guanylate Binding Protein 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - …

GBP1, the most widely studied GBP, has been studied for its antimicrobial properties. It can effectively polymerize and target the lipopolysaccharide cell wall of gram-negative bacteria.

Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics. In many cell …

Jul 1, 2019 · GBP1 thus acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes. Our findings expand the immune roles of human GBPs in regulating not …

Feb 22, 2022 · GBP1 identifies gram-negative bacteria such as the enteric pathogen, Salmonella enterica serovar Typhimurium, that enter the cytoplasm of the host cell. GBP1 then quickly …

Aug 16, 2020 · Guanylate binding protein 1 (GBP-1) promotes cell motility and invasiveness of lung adenocarcinoma. Yamakita I, et al. Biochem Biophys Res Commun, 2019 Oct 15. PMID …

Proteomics analysis of the tumor cells revealed Guanylate-Binding Protein 1 (GBP1) as a key T lymphocyte-induced protein that enables breast cancer cells to cross the blood-brain barrier …

Jan 24, 2024 · The dynamin-related human guanylate-binding protein 1 (GBP1) mediates host defenses against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 …

Jun 30, 2022 · GBP1 is a 65-kD GTPase protein in the GBP family that plays a crucial role in innate immunity 14, comprising a conserved region with an N-terminal globular GTPase …