γ-Aminobutyric acid sub-type A receptors (GABA A Rs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion channel with significant physiological and therapeutic implications.

There are two classes of GABA receptors: GABA A and GABA B. GABA A receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABA B receptors are G protein-coupled receptors, also called metabotropic receptors. Cell GABA A receptor.

May 25, 2022 · The GABA-A receptors (GABRA family of genes) are the most abundant and present throughout the central nervous system (brain, spinal cord). It is also found in immune cells and pancreatic beta-cells. GABA-B receptors (GABRAB1 gene) are more specialized.

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) genes are thought to be the targets of GABA B-mediated transcriptional regulation.

There are two main types of GABA receptors, the ionotropic GABA A receptor and the metabotropic GABA B receptor. In the adult brain, GABA acts primarily through activation of the fast hyperpolarizing GABA A receptors.

Apr 2, 2022 · Here, we summarize a comprehensive list of over 150 epilepsy-associated variants in the major α1, β2, β3, and γ2 subunits of GABA A receptors and their functional defects. In addition, their spatial distribution is visualized in the cryo-EM structures of GABA A receptors.

Oct 26, 2023 · Using eight available transcriptomic datasets from the human brain cortex of control individuals, we analyzed the mRNA expression of all 19 known GABA A Rs subunit genes in OPCs, with variations observed across different ages.

Mutations in inhibitory GABA A receptor subunit genes (GABRA1, GABRB3, GABRG2 and GABRD) have been associated with idiopathic epilepsy syndromes (IES) including childhood absence epilepsy (CAE), juvenile myoclonic epilepsy (JME), pure febrile seizures (FS), generalized epilepsy with febrile seizures plus (GEFS+), and Dravet syndrome (DS) (also ...

Aug 21, 2021 · Background: γ-Aminobutyric acid sub-type A receptors (GABA A Rs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion channel with significant physiological and therapeutic implications.

Oct 1, 2022 · Gamma-aminobutyric acid (GABA) is the most important inhibitory neurotransmitter in the brain and plays an important role in the occurrence and development of epilepsy. Abnormalities in all aspects of GABA metabolism, including GABA synthesis, transport, genes encoding GABA receptors, and GABA inactivation, may lead to epilepsy.