Regulation of small GTPases by GEFs, GAPs, and GDIs
Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
GDIs: central regulatory molecules in Rho GTPase activation
Jul 1, 2005 · The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs control the access of Rho GTPases to regulatory guanine nucleotide exchange …
The RHO Family GTPases: Mechanisms of Regulation and Signaling
GDI mediates the release of RHO GTPases from the membrane, maintains them in an inactivated state, and safeguards them against degradation or nonspecific activation by RHOGEFs [25, …
Regulation of the RhoGTPases by RhoGDI - Madame Curie …
The GDI proteins are key components of the regulatory machinery controlling both the timing and the localization of Rho GTPase activity. Recent structural work has provided significant insight …
Regulating Rho GTPases and their regulators - Nature
Jun 15, 2016 · Guanine nucleotide dissociation inhibitors (GDIs) sequester the GDP-bound form of some GTPases in the cytosol and prevent them from localizing to membranes or being …
Guanosine nucleotide dissociation inhibitor - Wikipedia
In molecular biology, the Guanosine dissociation inhibitors (GDI s) constitute a family of small GTPases that serve a regulatory role in vesicular membrane traffic.
Structural Insights into the Regulation Mechanism of Small …
Small GTPases are key regulators of cellular events, and their dysfunction causes many types of cancer. They serve as molecular switches by cycling between inactive guanosine diphosphate …
GDIs: central regulatory molecules in Rho GTPase activation
Jul 5, 2020 · The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs control the access of Rho GTPases to regulatory guanine nucleotide exchange …
Targeting the Small GTPase Superfamily through Their Regulatory ...
Apr 6, 2019 · This review explores the molecules targeting the GEF, GAP, and GDI GTPase regulatory proteins. It identifies issues in the chemical strategies, including PAINs motifs, …
Small GTPases and their GAPs - PMC
Here we review developments leading to current understanding of intrinsic and GAP catalyzed GTP hydrolytic reactions in small GTPases from structural, molecular and chemical …