GSK3 has been shown to phosphorylate several upstream and downstream components of the PI3K/AKT/mTOR signalling network, including AKT itself, RICTOR, TSC1 and 2, PTEN and …

Nov 27, 2021 · GSK3α has also been shown to regulate Akt in a manner unique from GSK3β, as GSK3α has been reported to promote the activating phosphorylation of Akt, which may be a …

Aug 17, 2017 · Glycogen synthase kinase 3β (GSK3β) is a multifunctional protein kinase involved in many cellular activities including development, differentiation and diseases. GSK3β is …

Less attention has been paid to the role of glycogen synthase kinase 3 β (GSK3β), a target of AKT. AKT is a serine/threonine kinase activated by a dual regulatory mechanism that requires …

Oct 20, 2016 · Importantly, we demonstrated by pharmacological inhibition and siRNA knockdown that GSK3β signaling is responsible, at least in part, of the apoptosis triggered by AKT …

Aug 1, 2017 · GSK3 has been shown to phosphorylate several upstream and downstream components of the PI3K/AKT/mTOR signalling network, including AKT itself, RICTOR, TSC1 …

Apr 1, 2013 · High NaCl activates the transcription factor nuclear factor of activated T cells 5 (NFAT5), leading to increased transcription of osmoprotective target genes. Kinases PKA, …

Much less attention has been paid to the role of glycogen synthase kinase 3 β (GSK3β), a target of AKT. In this review we focus on the function of AKT/GSK3β signaling in GBM. Keywords: …

In mammals GSK3 exists in two forms, GSK3a and GSK3b, paralogs which share a highly conserved catalytic domain but differ at both termini and are encoded by separate genes, in …

Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. [5] [6] In mice, the enzyme is encoded by the Gsk3b gene. [7] Abnormal …