These mice are useful when for characterizing innervation of Grp sensory neurons and studying the role of Grp spinal neurons in itch and pain.

Tamoxifen诱导Cre-ERT2小鼠 使用指南. Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。 查看

Mar 13, 2020 · To determine the role of GRP in sensory neurons, we generated a floxed Grp mouse line. We found that conditional knockout of Grp in sensory neurons results in attenuated non-histaminergic itch,...

To specifically activate spinal and supraspinal GRP neurons by the designer receptors exclusively activated by designer drugs (DREADDs) system, CAG‐LSL‐Gq‐DREADD mice were crossed with GRP‐Cre mice, resulting in the development of GRP‐hM3Dq mice.

We first characterized the Ntsr1-GN209-Cre and Grp-KH288-Cre mice, which have been widely used to target WFV and NFV cells, respectively.

Oct 4, 2022 · Gastrin-releasing peptide (GRP) and its receptor (GRPR) in the suprachiasmatic nucleus (SCN) of the hypothalamus mediates contagious itch behavior in mice.

View Tg (Grp-cre)KH288Gsat allele: origin, molecular description, gene associations, and references.

The Grp-iCre mouse was constructed by integrating the Kozak-iCre-WPRE-BGH pA expression cassette into the mouse Grp gene, disrupting the expression of the endogenous mouse Grp gene.

Jun 25, 2020 · To determine the involvement of spinal GRP + neurons in IMQ‐induced psoriatic itch, we conducted chemogenetic silencing of GRP + neurons by crossing R26‐LSL‐Gi‐DREADD mice and GRP‐Cre mice.

Feb 20, 2025 · iCre was knocked in at the translation initiation site of the gastrin-releasing peptide (Grp) gene. Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.