Gas chromatography–mass spectrometry (GC–MS) is an analytical method that combines the features of gas-chromatography and mass spectrometry to identify different substances within a test sample. [1]

Feb 16, 2024 · Gas chromatography mass spectrometry (GC-MS) is an important technique in the analytical chemist's armory. In this article we explore how GC-MS and GC-MS/MS work, what they can tell us, their strengths, weaknesses and applications.

This GCMS primer explains the fundamentals of gas chromatography mass spectrometry, and provides the basics of GC/MS theory and technique for the gas chromatograph (GC) and the mass spectrometer (MS) with ion source, quadrupole mass analyzer, and detector.

Apr 19, 2023 · Gas chromatography mass spectrometry (GC-MS) is an analytical technique that combines two powerful techniques; gas chromatography and mass spectrometry and is used to separate, identify, and quantify volatile compounds. It is therefore perfect for analyzing the many relatively low molecular weight compounds.

In 1955-56, Dow Chemical scientists Fred McLafferty and Roland Gohlke first demonstrated the combination of gas chromatography (GC) and mass spectrometry (MS) to identify individual substances in a mixture.

GC-MS employs gas chromatography, sending components through a chromatography column that is heated in an oven so that compounds can be separated out largely based on their boiling points.

GC-MS is often used to qualitatively and quantitatively determine organic compound purity and stability and to identify components in a mixture. GC-MS is commonly used in many disparate fields, including environmental chemistry for atmospheric, soil, and water research; forensic

Discover the differences between GC, GC-MS, and GC-HS techniques, their applications, and the importance of high-purity solvents for accurate analytical results.

Feb 12, 2023 · What is Gas Chromatography-Mass Spectrometry (GC-MS)? GC-MS is the separation technique of choice for smaller volatile and semi-volatile organic molecules such as hydrocarbons, alcohols, and aromatics, as well as pesticides, steroids, fatty acids, and hormones.

Gas chromatography combined with a triple quadrupole mass spectrometry system is referred to as GC-MS/MS. The triple quadrupole MS provides a higher level of selectivity and is best suited to analyses where the highest sensitivity is required.