This test includes a charge for the probe application, analysis, and professional interpretation of results for 4 probe sets (8 individual fluorescence in situ hybridization [FISH] probes). Additional charges will be incurred for all reflex or additional probe sets performed.

Acute myeloid leukemia (AML) is a clinically, morphologically and genetically heterogeneous disease that results in clonal expansion of myeloid blasts in the peripheral blood, bone marrow, or other tissue.

Mar 4, 2025 · Reflex results will be reported separately as AML Standard Reflex Panel. Disease (s): Acute myeloid leukemia. Note: STAT processing is available by request for PML-RARA. Note STAT along with MD contact name and phone number to receive STAT results. 3-5 Days.

Mar 31, 2025 · FISH for acute myelocytic leukemia (AML), targeting rearrangement of PML-RARA, CBFB, RUNX1/RUNX1T1, KMT2A and numerical changes of 5q, and 7q. This test is a diagnostic and prognostic test for acute myeloid leukemia; detection rate is 80% of the known chromosome causes of AML.

This FISH panel is designed to detect the most common, and/or prognostically-significant abnormalities in AML with recurrent genetic abnormalities and in therapy-related AML (Swerdlow et al. 2008). Recurrent abnormalities are observed in the majority of AML cases.

Ten patients with acute myeloid leukemia (AML) harboring KMT2A CNV had a complex karyotype, a negative prognostic factor in AML. Adding FISH of KMT2A to routine detection leads to more accurate detection of KMT2A -r and improved identification of KMT2A CNV, which would benefit patients by improving the risk stratification in AL.

This test is intended for instances when limited acute myeloid leukemia (AML) fluorescence in situ hybridization (FISH) probes are needed based on specific abnormalities or abnormalities identified in the diagnostic sample.

Aug 21, 2023 · Use to identify cytogenetic abnormalities with diagnostic and prognostic significance in suspected or newly diagnosed acute myeloid leukemia (AML). To monitor therapeutic response using specific probes, refer to Chromosome FISH, Interphase (2002298).

FISH continues to be a powerful technique in the diagnosis of AML, with higher resolution than conventional cytogenetic analysis, rapid turnaround time, and a considerable diagnostic and prognostic utility.

Ordering Recommendation: FISH is useful to identify and track chromosome abnormalities in patients with acute myeloid leukemia (AML) for diagnostic and prognostic purposes as well as for follow-up to evaluate patient response to therapy.