The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point …

This review summarizes the structure of FGFR, especially its kinase domain, and the development of small molecule FGFR inhibitors. Keywords: fibroblast growth factor receptors, structure, kinase inhibitor, targeted therapy

Sep 2, 2020 · Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult...

The cellular response to FGFR signaling is regulated by differences in the intrinsic signaling properties of FGFRs and by the dynamics of subcellular FGFR trafficking in response to ligand binding.

Aberrant FGFR signaling is largely attributed to several underlying mechanisms involving gene amplification, single nucleotide polymorphism (SNP), chromosomal translocation, ligand availability and impaired termination program in FGF-mediated signaling, which is reviewed in the following section.

FGF/FGFR signaling participates in the development of almost all organ such as lung, heart, urinary system, brain, skeleton, muscle, and skin/appendage, as well as angiogenesis and...

Jun 3, 2024 · Dysregulation of this pathway is implicated in numerous human cancers, positioning FGFR as a prominent therapeutic target. Here, we conduct a comprehensive review of the function, signaling pathways and abnormal alterations of FGFR, as well as its role in tumorigenesis and development.

Dec 18, 2024 · This review provides a comprehensive overview of FGF-FGFR signaling pathways while highlighting their complex regulatory mechanisms and interconnections with other signaling networks. Further, we briefly discuss the FGFs involvement in developmental, metabolic, and housekeeping functions.

Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD 331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family.

Fibroblast Growth Factors Receptors (FGFRs) are often overexpressed in tumors, and mutations of the FGFR genes have been found in human cancers, making it particularly significant that FGFR activation in endothelial cell culture and animal models leads to angiogenesis [37].