In HCC, FGF18 can be induced by Wnt/β-catenin and secreted from HCC cells and HUVECs. FGF18 binds to its receptor FGFR3 and activates downstream AKT and ERK signaling to …

Aberrant expression of fibroblast growth factor 19–fibroblast growth factor receptor 4 (FGF19–FGFR4) is reported to be an oncogenic-driver pathway for HCC patients. Thus, the …

Mar 17, 2021 · In this review, we summarize the recent discoveries relating to FGF/FGFR signaling in HCC. We discuss the roles of FGF/FGFR signaling in HCC initiation and …

In HCC, overexpression of FGF19/FGFR4 significantly correlates with epithelial cell adhesion molecular expression, which is a marker of hepatic cancer stem cells within the fatty …

Mar 17, 2021 · This review summarizes the aberrant FGF/FGFR signaling in HCC initiating, development and treatment status, and provide new insights into the treatment of HCC. …

Therefore, in this article, we will briefly describe recent advances in the physiological function and molecular mechanism of FGF in HCC. We also present the current chemical inhibitors of …

Nov 3, 2015 · On the basis of these results, we conclude that the FGFR pathway is critical for HCC survival, and that targeting this pathway with AZD4547 may be beneficial for the …

Mar 17, 2021 · Noticing an explosion in the number of studies about aberrant FGF/FGFR signaling in HCC being studied, we were encouraged to summarize them. This review …

The fibroblast growth factor receptor (FGFR) pathway is increasingly acknowledged to play a role in the pathogenesis of hepatocellular carcinoma (HCC) and is postulated to be upregulated as …

Jan 15, 2012 · FGF-2 stimulation on HCC cells resulted in increasing NK sensitivity against HCC cells. These findings indicate that FGF-2 produced by HCC cells or normal hepatocytes of …