For most types of cancer, determining the stage (extent) of the cancer is very important. The stage is based on the size of the main tumor and how far the cancer has spread. This can be helpful in predicting a person’s outlook and deciding on treatment. Acute myeloid leukemia (AML), on the other hand, does not usually form tumors.

Minimally differentiated acute myeloblastic leukemia is a subtype of AML. It is classified as M0 by FAB. It represents 2–3% of all cases of AML. [1] . Although minimally differentiated AML was recognized earlier, criteria for FAB M0 were developed in 1987. [2] .

Oct 27, 2023 · There are 2 staging systems that are commonly used during diagnosis of acute myeloid leukemia (AML). The French-American-British (FAB) classification system is based on morphology to define...

Mar 1, 2013 · Leukemia acute - Acute myeloid leukemia with minimal differentiation (FAB AML M0)

fab m0. Marrow blasts from patients with this undifferentiated type of acute myelogenous leukemia can have variable amounts of agranular cytoplasms. Cells are peroxidase- and Sudan black-negative and can be confused with FAB M7 or FAB L2.

Myeloid Leukemia with Minimal Differentiation - FAB M0. M0 is an acute leukemia with no evidence of myeloid differentiation by light mocroscopy. Immunophenotyping studies are essential in all cases to distinguish this disease from acute lymphoblastic leukemia (ALL).

Jan 15, 1997 · We compared the immunophenotypic and karyotypic features of 25 cases of minimally differentiated acute myeloid leukemia (AML-M0) with those of 247 cases comprising all AML French-American-British (FAB) classification.

Dec 7, 2006 · This study examines the incidence, pretreatment characteristics, and outcome of the FAB AML-M0 subtype in prospectively enrolled pediatric patients treated on 2 consecutive but similarly intensive treatment protocols.

A 2013 study showed evidence that, there is a significant difference in survival (complete remission, relapse-free survival, and overall survival) between patients with AML M0 and patients with AML M1, M2, M4, M5, or M6.

Mar 28, 2013 · After multivariate adjustment, FAB M0 was independently associated with significantly lower likelihood of achieving complete remission and inferior relapse-free and overall survival as compared with FAB M1, M2, M4, M5, and M6, with inconclusive data regarding M7.