Forkhead box protein F1 (FOXF1) is a protein that in humans is encoded by the FOXF1 gene. [5][6][7] This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FOX1 protein is important in the development of the pulmonary mesenchyme and the development of the gastrointestinal tract. [8]

Mar 30, 2025 · FOXF1 (Forkhead Box F1) is a Protein Coding gene. Diseases associated with FOXF1 include Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins and Idiopathic/Heritable Pulmonary Arterial Hypertension. Among its related pathways are Cell junction organization and Regulation of CDH11 Expression and Function.

The FOXF1 gene provides instructions for making the forkhead box F1 (FOXF1) protein. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of many other genes.

May 4, 2023 · Focusing on FOXF1, we found that FOXF1 is decreased in EC within human idiopathic pulmonary fibrosis (IPF) and mouse bleomycin-injured lungs. Endothelial-specific Foxf1 inhibition in mice...

Sep 26, 2014 · FOXF1 is required for the formation of embryonic vasculature by regulating endothelial genes critical for vascular development and vascular endothelial growth factor signaling.

Jun 19, 2024 · Mutations in the FOXF1 gene, a key transcriptional regulator of pulmonary vascular development, cause Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, a lethal lung disease...

The FOXF1 (Forkhead box F1) gene, located on chromosome 16q24.1 encodes a member of the FOX family of transcription factors characterized by a distinct forkhead DNA binding domain. FOXF1 plays an important role in epithelium-mesenchyme signaling, as ...

We identified Forkhead box F1 (FOXF1) as a critical regulator of EC-to-TEC transition. FOXF1 was highly expressed in normal lung vasculature but was decreased in TEC within non-small cell lung cancers (NSCLC). Low FOXF1 correlated with poor overall survival of NSCLC patients.

Cai et al. found that, in adult lung endothelial cells, the transcription factor FOXF1 transcriptionally activated a gene encoding the receptor for S1P, a lipid mediator that enhances the barrier function of endothelial cells.

Dec 25, 2023 · Clinical resource with information about FOXF1, A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus., Alveolar capillary dysplasia with pulmonary venous misalignment, Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus., Genome-wide SNP ...