Mar 14, 2021 · Transcription factor forkhead box P1 (FOXP1) is a crucial modulator in skeletal development and aging. Here, we determined the role and regulatory mechanisms of FOXP1 …

Nov 1, 2005 · C-Fos expression correlated significantly with cell-cycle promoters (cyclins E and B1, cdk2 and cdk4) and cell-cycle inhibitors (p16, p21, Rb). The latter proteins are often …

Taken together, we demonstrate that FOXP1, which is transactivated by ERK/JNK-c-JUN/c-FOS, drives osteosarcoma development by regulating the p53-P21/RB signaling cascade, …

Sep 16, 2013 · These data demonstrate that rapid early epidermal responses to rasHa/fos/ΔPTEN co-operation involve induction of p53/p21 to alter differentiation and divert …

Jun 30, 2005 · Hikasa et al. (2003) determined that c-fos overexpression led to downregulated phosphorylation and dimerization of STAT1, which in turn downregulated p21 gene …

p21 SNFT (21-kDa small nuclear factor isolated from T cells) is a novel human protein of the basic leucine zipper family. The overexpression of p21 SNFT leads to the significant and specific …

Dec 1, 2008 · In this experiment, we address the role of ATO-induced ERK1/2 activation in the binding of c-Fos to the p21 promoter. To measure binding, ATO treatment was followed by …

The cyclin-dependent kinase (cdk) inhibitor p21(Cip1/WAF1) is a negative regulator of cdk activity, thereby impeding cell cycle progression. By sequence analysis, we identified a putative AP-1 …

May 15, 2008 · Thus, Fos synergism with Pten loss elicited a benign tumour context where GSK3β-induced p53/p21 WAF expression continually switched AKT-associated proliferation …

Jan 15, 1992 · The point-mutated c-Ki-ras p21 (c-Ki-rasval12 p21) is known to strongly transform NIH/3T3 cells and to markedly stimulate the c-fos promoter/enhancer in this cell line, whereas …