Aug 26, 2022 · By contrast, the FN1- related molecular pairs, including FN1 - CD44 (a marker of cancer stem cells) and FN1 - (ITGAV + ITGB1), were prompted between SELENOP -Mφ/ SPP1 -Mφ and FABP4 -Mφ/ FCN1...

Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. The lymphocyte-high endothelial venule (HEV) cell interaction is an essential element of the immune system, as it controls lymphocyte recirculation between blood and lymphoid organs in the body.

Jan 2, 2022 · Silencing CD44 and FN1 in EO771 cells and MDA-MB-231 cells downregulated MTT-based viability as well as the expression of Lrp5, MMP9, Runx2, and Snail in EO771 cells, whereas their silencing significantly suppressed MSN-induced tumor inhibition (Figure 7 D-E, Figure S10 B-D).

It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations including cellular localization, molecular function and biological process, drugs, diseases, genome-wide association studies (GWAS), GO enrichments, PDB ID, Uniprot ID, HPRD ID, and word cloud from pubmed abstracts.

Mar 1, 2024 · The results demonstrated highly active secretion protein pathways such as FN1-CD44, FN1-ITGAV_ITGB1, FN1-ITGA5_ITGB1, COL9A2-ITGA1_ITGB1, COL9A2-CD44, ANGPTL4-SDC2, ANGPTL4-SDC3, ANGPTL4-CDH5, ANGPTL4-CDH11, and ANGPTL4-ITGA5_ITGB1 in the cisplatin-resistant epithelial clusters (Fig. 2C).

Mar 1, 2025 · FN1 may interact with CD44 receptors on stem/TA-like cells, potentially activating signaling pathways (ERK1/2, PI3K/AKT) that upregulate FOS and its targets, enhancing invasive phenotype of these cells.

In particular, in contrast to intracellular moesin, extracellular moesin exerts a tumor-suppressive effect by regulating cell adhesion through inhibition of Src and β-catenin signaling via its interaction with the CD44 extracellular domain and FN1.

Nov 28, 2024 · This study identifies hub genes such as FN1 and CD44, with potential diagnostic value in DN. It also reveals immune cell infiltration differences between DN patients and controls, offering insights into disease progression and potential therapeutic targets.

Jul 12, 2022 · Four hub genes (FN1, CD44, C1QB, and C1QA) were screened out by the "UpSetR" package, and FN1 was identified as a key gene for DN by logistic regression analysis.

Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively.