Daporinad (FK866) 是烟酰胺磷酸核糖转移酶 (NMPRTase; Nampt) 的有效抑制剂， IC50 为 0.09 nM。 - 高纯度，全球文献引用。 — Master of Bioactive Molecules

Nov 1, 2003 · We identified the first low molecular weight compound, designated FK866, which induces apoptosis by highly specific, noncompetitive inhibition of nicotinamide …

Nov 11, 2003 · FK866 effectively inhibited cell growth with IC 50 concentrations between 1 and 3 n m, depending on the assay system. The concentration response curves illustrated as …

Daporinad (FK866)有效抑制烟酰胺磷酸核糖转移酶(NMPRTase; Nampt)，Daporinad (FK866) 可引发自噬，无细胞试验中IC50为0.09 nM。Phase 1/2。 靶点

fk866 是一种有效且特异性的 nampt 小分子抑制剂。 本研究的目的是验证 NAD 消耗对增殖的影响，并阐明小细胞肺癌 (SCLC) 细胞系中细胞死亡的机制。 方法：SCLC 化疗敏感细胞系（NCI …

FK866 (APO866, Daporinad)有效抑制烟酰胺磷酸核糖转移酶(NMPRTase)，无细胞试验中IC50为0.09nM。Phase 1/2。 信号通路 Metabolism 靶点 NMPRTase － － － － IC50 0.09nM － － …

The dose limiting toxicity of FK866 is thrombocytopenia. Pharmacokinetic data suggest an increase in the plasma Css in relation to the escalation of FK866. The recommended phase II …

fk866是一种高特异性的和非竞争性的烟酰胺磷酸核糖转移酶（nampt）抑制剂，ki值为0.4 nm。 靶点: nampt: 生物活性数据: 0.4 nm (ki)

Daporinad (FK866) is one of the highly specific inhibitors of nicotinamide phosphoribosyl transferase (NAMPT) and known to have its unique mechanism of action that induces the …

Oct 3, 2016 · Nampt inhibition with (E)-Daporinad (FK866) induces significant NAD + intracellular reduction and selectively kills MM cells. (E)-Daporinad (FK866)-induced cell death is …