During early lens development, Fgfr1 is first detected in lens vesicle and cornea, but its expression level increases with the onset of primary fiber cell differentiation.

Mar 1, 2011 · We found that transcripts encoding several FGF ligands and the four classical FGF receptors are detectable in the lens-forming ectoderm at the time of lens induction. Conditional …

Jan 8, 2011 · The amplified DNA was detected using probe and image processing was used to compare the cell area, the average absorbance and integral absorbance. The study indicates …

RT-PCR analyses reveal that a number of FGF family members are expressed in cornea epithelium and retinal tissues both before and during the process of lens regeneration. Of …

Jan 10, 2006 · Results: Fgfr1 null embryonic stem cells were able to rescue normal embryonic lens development in chimeric combination with aphakia mutant embryos. In addition, …

We previously showed that Discs large-1 (Dlg-1) regulates lens fiber cell structure and the fibroblast growth factor receptor (Fgfr) signaling pathway, a pathway required for fiber cell …

Jan 23, 2018 · FGF loss- and gain-of-function experiments demonstrated that Crk proteins act downstream of FGF signaling to enhance ERK phosphorylation. Contrary to the previous belief …

Jan 8, 2011 · Aim: To study the differences of fibroblast growth factor receptor 1 (FGFR1) gene on human lens epithelial cells (HLECs) of adults and fetuses. Methods: Indirect in situ RT-PCR …

Jun 15, 2008 · Deletion of three FGF receptors (Fgfr1–3) early in lens development demonstrated that expression of only a single allele of Fgfr2 or Fgfr3 was sufficient for grossly normal lens …

May 13, 2014 · In this study, we address the possibility that Dlg-1, a newly discovered PCP gene, is a regulator of the Fibroblast growth factor receptor (Fgfr) signaling pathway in the terminal …