The roles of EZH2 in cancer and its inhibitors - PMC
This review summarized the mechanisms that EZH2 regulates gene transcription and the interactions between EZH2 and important intracellular signaling molecules (Wnt, Notch, MEK, …
EZH2 - Wikipedia
Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in histone methylation and, ultimately, …
EZH2-targeted therapies in cancer: hype or a reality - PMC
Aberration of EZH2 signaling in cancer. EZH2 is overexpressed in numerous tumor entities including melanoma, ovarian, breast, endometrial, bladder, renal cell, lung, and liver cancer, …
EZH2-associated tumor malignancy: A prominent target for cancer ...
Jun 17, 2024 · EZH2 signaling triggers cancer progression and may intervene with anti-tumor immunity; therefore it has charmed attention as an effective therapeutic target in cancer …
EZH2: a novel target for cancer treatment | Journal of Hematology ...
Jul 28, 2020 · Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive complex 2 (PRC2) that can alter downstream target genes expression by …
EZH2: biology, disease, and structure-based drug discovery
Dec 23, 2013 · In this review, we address the current understanding of the oncogenic role of EZH2, including its PRC2-dependent transcriptional repression and PRC2-independent gene …
The long and short non-coding RNAs modulating EZH2 signaling …
Mar 2, 2022 · EZH2 signaling and its role in regulating downstream signaling pathways. Epigenetic regulation of molecular mechanisms in cells such as DNA repair, cell cycle, …
EZH2 as a new therapeutic target in brain tumors: Molecular …
Feb 1, 2022 · EZH2 signaling mainly participates in increasing proliferation and invasion of cancer cells. However, in medulloblastoma, EZH2 demonstrates tumor-suppressor activity. …
EZH2 as a Regulator of CD8+ T Cell Fate and Function - PMC
In this review, we will focus on the role of the dynamic expression EZH2 in shaping the epigenetic landscape of CD8+ T cell fate and function, with a particular emphasis on infection and …
EZH2, a prominent orchestrator of genetic and ... - ScienceDirect
Mar 1, 2022 · EZH2 orchestrates the regulation of the innate and adaptive immune systems of the tumor microenvironment (TME). Profound epigenetic and transcriptomic changes induced by …