Here, we show a mechano-chemical regulatory sys-tem underlying lung branching morphogenesis, orchestrated by extracellular signal-regulated kinase (ERK) as a downstream driver of FGF signaling. We found that tissue-scale curvature regulated ERK activity in the lung epithelium using two-photon live cell imaging and mechanical perturbations.

Erks function as the sole targets of the receptor tyrosine kinases (RTKs)-Ras-Raf-MEK signaling cascade, which controls numerous physiological processes and is mutated in most cancers. …

Jul 17, 2024 · As mice age, IL-11 is upregulated across cell types and tissues to regulate an ERK–AMPK–mTORC1 axis to modulate cellular, tissue- and organismal-level ageing pathologies. Deletion of Il11...

Extracellular signal-regulated kinase (ERK) has been recognized as a critical regulator in various physiological and pathological processes. Extensive research has elucidated the signaling mechanisms governing ERK activation via biochemical regulations with upstream molecules, particularly receptor …

Feb 26, 2024 · Here, we show a mechano-chemical regulatory system underlying lung branching morphogenesis, orchestrated by extracellular signal-regulated kinase (ERK) as a downstream driver of FGF signaling.

My laboratory focuses on a number of host and pathogen proteins that play important roles in infectious diseases. The project encompasses studies of molecular mechanisms of bacterial and viral pathogenesis in the context of disease processes.

In this study, we investigate whether IL11-stimulated ERK/P90RSK can phosphorylate LKB1 (STK11) to inac-tivate LKB1/AMPK and increase mTOR activity.

Here we explore the impact of ERK-mediated mechanical interactions on tissue morphogenesis, cell extrusion in homeostasis, and their interplay with the physical microenvironments of the extracellular matrix.

Thus, we found that Cif induces a potent and selective activation of the pro-survival mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway. We sought to characterize the mechanism through which Cif activates ERK.

Subsequently, Western blotting (WB) detected the expression of epidermal growth factor receptor (EGFR), and the important signaling pathway proteins Ras/ERK and AKT/mTOR. Results showed that it could downregulation of EGFR protein expression and inhibit of activation of ERK/AKT signaling pathways.