These data reveal that Cav-1 promotes phosphorylation of transcription factors Hnf4a and Sp1, which bind to the Rfng promoter region, via the MAPK signaling pathway, to induce the transcription of Rfng.

Cav-1, which is increased significantly in RCC kidney tissue, can regulate the growth and metastasis of cancer cells (Joo et al., 2004; Steffens et al., 2011). In addition, the expression of Cav-1 and phosphorylated ERK-1/2 in local RCC tissues is also considered to be a predictor of metastasis of RCC (Campbell et al., 2013).

Caveolin-1 (Cav-1), the main scaffold protein present in MLRs, targets many neural growth proteins and promotes growth of neurons and dendrites. Targeting Cav-1 may be a promising therapeutic strategy to enhance neuroplasticity after cerebral ischemia.

Apr 15, 2023 · Following the block of Cav-1 expression by methyl β-cyclodextrin, eNOS expression decreased, and KLF2 and p-ERK expression increased. OSS may lead to endothelial cell dysfunction by Cav-1-mediated KLF2/eNOS/ERK signaling pathway.

Cav-1 small interfering RNA (siRNA) reduced eNOS protein and gene expression in association with a twofold increase in eNOS phosphorylation and nitrate production per molecule of eNOS, which was reversed in cells overexpressing Adv-Cav-1-GFP.

Interferon-induced transmembrane protein 1 (IFITM1) is an essential mediator of interferon-g-induced antiproliferation. Here, we reported the interaction between IFITM1 and caveolin-1 (CAV-1), and their inhibitory regulatory function on extracellular signal-regulated kinase (ERK).

Dec 6, 2019 · Extracellular signal-regulated kinase1/2 (ERK1/2) pathway is involved in the process of VSMCs proliferation and migration. In the present study, we explore the effects of Caveolin-1-ERK1/2 pathway and uremia toxins on the endothelial cells and VSMCs following shear stress application.

Nov 14, 2019 · Caveolin-1 (cav-1), the principal structural and signalling protein of caveolae, is implicated in various signalling events, including apoptotic cell death in type 2 diabetes. However, the...

Sep 16, 2019 · This study demonstrates that Cav-1 affects expression of the glycosyltransferase, Rfng, by regulating the Erk-Jnk-p38 signaling pathways, providing a new theoretical basis and support for explaining the involvement of Cav-1 in the …

May 1, 2022 · CAV1 has been shown to influence the MEK/ERK signalling pathway with contrasting effects arising in low- and high- CAV1 expressing cells through mutual adjustment of the RAF/ERK negative feedback loop.