Mar 30, 2025 · ERCC3 (ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit) is a Protein Coding gene. Diseases associated with ERCC3 include Trichothiodystrophy 2, Photosensitive and Xeroderma Pigmentosum, Complementation Group B.

The ERCC3 gene variant that causes xeroderma pigmentosum changes one amino acid in the XPB protein. Specifically, the variant replaces the amino acid phenylalanine with the amino acid serine at protein position 99 (written as Phe99Ser or F99S).

Mar 28, 2025 · This study is the first to reveal the association between high ERCC3 expression and poor prognosis in HCC and to elucidate its immunomodulatory role in HCC. Unlike previous studies, we found that ERCC3 promotes HCC progression by regulating the inflammatory microenvironment and immune checkpoints.

Reduced protein expression levels of DNA excision repair protein ERCC-3 (ERCC3) and XPA nucleotide excision repair protein (XPA) were associated with an increased risk of squamous cell carcinoma of head and neck (SCCHN).

In recent years, the excision repair cross-complementation group 3 gene (ERCC3) was proposed as a susceptibility gene for breast cancer. Genetic heterogeneity and population-specific frequencies of ERCC3 mutations were observed in cohorts from diverse geographical and ethnic backgrounds [9 – 12].

A recurrent heterozygous ERCC3 truncating mutation increases the risk for breast cancer in patients with Ashkenazi Jewish ancestry. Our study aimed to investigate the role of ERCC3 truncating variants in a cohort of patients with suspicion of HBOC.

Excision repair cross-complementation group 3 (ERCC3) is a gene that encodes a protein that is involved in nucleotide excision repair. Missense mutations, silent mutations, nonsense mutations, and in-frame deletions are observed in cancers such as …

We further showed that triptolide down-regulated the expression of c-Myc through targeting ERCC3, a newly identified triptolide-binding protein. CONCLUSIONS: The triptolide-induced modulation of c-Myc/miRNA clusters/target genes axis enhances its potent antitumor activity, which indicates that triptolide serves as an attractive chemotherapeutic ...

To examine the significance of the postulated functional domains in ERCC3, we have introduced mutations in the ERCC3 cDNA by means of site-specific mutagenesis and have determined the repair capacity of each mutant to complement the UV-sensitive phenotype of rodent group 3 cells.

A gene that makes a protein involved in the first step of making proteins and in repairing damaged DNA. Mutations (changes) in the ERCC3 gene may cause cells to lose their ability to repair damaged DNA, which may lead to abnormal cell growth.