Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene. [5][6] Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system.

Mar 30, 2025 · EPHB3 (EPH Receptor B3) is a Protein Coding gene. Diseases associated with EPHB3 include Giant Axonal Neuropathy 2 and Craniofrontonasal Syndrome. Among its related pathways are GPCR Pathway and EPH-Ephrin signaling.

Apr 13, 2020 · The protein tyrosine kinase Ephrin type-B receptor 3 (EPHB3) is expressed in cells at the base of intestinal crypts, acting as a cellular guide in the maintenance of intestinal crypt architecture. We aimed to investigate the expression profile of EPHB3 in colorectal precancerous lesions and colorect …

Jan 8, 2018 · Specifically, we identified that EphB3 receptors function as a pro-apoptotic dependence receptor in endothelial cells (ECs) that contributes to increased BBB damage after CCI injury.

EphB3 provides critical support to the development and progression of NSCLC by stimulating cell growth, migration, and survival. Ephrin B3 receptor regulates the synthesis and release of D-serine in astrocytes, which may have important implications on synaptic transmission and …

In the mouse small intestine, EphB2 is highly expressed on stem cells in crypts of villi while EphB3 is highly expressed on differentiated Paneth cells. The gradients of these receptors and their cognate ephrin-B1/B2 ligands tightly control cellular positioning and stem-cell differentiation and proliferation ( 99 , 100 ).

Aug 8, 2016 · Thus, EphB3 contains a unique reactive feature that can be exploited for the development of specific irreversible inhibitors of EphB3. Herein, we report the design, synthesis, optimization, and biological characterization of a series of electrophilic quinazolines as irreversible inhibitors of EphB3.

Our The Cancer Genome Atlas (TCGA) data analysis showed that EphB3, a receptor tyrosine kinase, is frequently coamplified with PIK3CA in head and neck squamous cell carcinoma (HNSCC). We therefore hypothesized that EphB3 amplification plays a protumorigenic role in HNSCC and that EphB3 and PIK3CA are cooperating oncogenes that contribute toward ...

May 8, 2014 · We show that EphB3 co-labels with microtubule-associated protein 2-positive neurons in the adult cortex and is closely associated with ephrinB3 ligand, which is reduced following controlled...

The findings that macrophages in the injured optic nerve express EphB3 and that EphB3 is an essential component for adult RGC axon re-extension may provide some mechanistic insight into how macrophages perform their supportive functions after CNS injury.