EZH2 overexpression dampens tumor-suppressive signals via an
Oct 2, 2020 · We revealed reciprocal regulation of early growth response 1 (EGR1) and EZH2: EGR1 activates the expression of EZH2, and EZH2 represses EGR1 expression. Using …
Reciprocal regulation of EZH2 and EGR1 is implicated in breast...
In this study, we developed an approach to systematically identify the trans-acting factors regulating the EZH2 expression, and identified more than 20 such factors.
EGR1 upregulates the expression of EZH2 in breast cancer cells a EGR1…
EZH2 overexpression was described to play a crucial role in breast cancer pathogenesis, where it represses early growth response 1 (EGR1) expression, resulting in the inhibition of...
The Immediate Early Gene Product EGR1 and Polycomb Group …
We report novel molecular connections between EGR1 and Polycomb Group function: Polycomb associated histone H3 lysine27 trimethylation (H3K27me3) blocks chromatin access of EGR1. …
The roles of EZH2 in cancer and its inhibitors - PMC
EZH2 is involved in the cell cycle, DNA damage repair, cell differentiation, autophagy, apoptosis, and immunological modulation. The main function of EZH2 is to catalyze the methylation of H3 …
Paracrine and epigenetic control of CAF-induced metastasis: …
Jan 11, 2018 · Antibodies against human CDK5, CDK5RAP1, H3K27me3, EZH2 (1:1000 dilutions, Cell Signaling Technology), Egr-1, E-cadherin, vimentin, β-catenin (1:1000 dilutions, …
EZH2 overexpression dampens tumor-suppressive signals via an EGR1 …
Nov 26, 2020 · We revealed reciprocal regulation of early growth response 1 (EGR1) and EZH2: EGR1 activates the expression of EZH2, and EZH2 represses EGR1 expression. Using …
EZ Switch From EZH2 to EZH1 | Circulation Research
Jul 7, 2017 · EZH2, a histone methyltransferase, catalyzes H3K27me3, and it has been shown to be dysregulated in various cancers. EZH1 is an alternative core subunit to EZH2 in PRC2 …
Egr-1: new conductor for the tissue repair orchestra directs …
The Egr-1-binding protein Nab2 is an endogenous inhibitor of Egr-1-mediated signaling, and abrogates the stimulation of fibrotic responses induced by transforming growth factor-ß (TGF-ß).
EZH2 overexpression dampens tumor-suppressive signals via an EGR1 …
Oct 2, 2020 · We revealed reciprocal regulation of early growth response 1 (EGR1) and EZH2: EGR1 activates the expression of EZH2, and EZH2 represses EGR1 expression. Using …
- Some results have been removed