Nov 29, 2023 · We identified the induction of lysine demethylase 6B (KDM6B) as the primary epigenetic driver of early immunofibroblast differentiation. In addition, we observed an …

Dec 5, 2020 · In this study, we evaluated the function of these two enzymes using an EMT-inducible model, the lung cancer A549 cell line. ChIP-seq coupled with transcriptomic analysis …

Oct 7, 2013 · The in vivo ectopic bone formation potential of vector control MSC (Control), Ezh2 over-expressing MSC (Ezh2), or Kdm6a over-expressing MSC (Kdm6a) was assessed 8 …

Both Ezh2 and Kdm6a were shown to affect expression of master regulatory genes involved in adipogenesis and osteogenesis and H3K27me3 on the promoters of master regulatory genes. …

Overexpression of CDK4/6 or Rb1 knockout confers neuroblastoma cell resistance to both palbociclib and the KDM6 inhibitor GSK-J4. These data indicate that KDM6B promotes an …

We showed that lung cancer patients presenting high EZH2 mRNA levels or high KDM6B mRNA levels presented a significantly higher risk of early death (p = 3.4 ×10 −5 and p = 4.8 × 10 −5) …

Jan 31, 2023 · KDM6 proteins are histone-3-lysine-27-demethylases that play context-dependent roles in AML. We inform that KDM6-demethylase function critically regulates DNA-damage …

Jan 6, 2021 · Lysine (K)-specific demethylase 6B (KDM6B), also called jumonji domain-containing protein D3 (JMJD3), could counter the effect of EZH2.

Mar 15, 2019 · Here, we report that hypoxia promotes histone methylation in a HIF- and 2-HG–independent manner. We found that the H3K27 histone demethylase KDM6A/UTX, but …

The mutation status of the lysine demethylase 6 A (KDM6A), a gene antagonist to Enhancer of zeste homolog 2 (EZH2), is closely related to the therapeutic efficacy of EZH2 inhibitors in …