SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell ... - Nature
Dec 29, 2022 · SHP-2 and the PD-1-SHP-2 signaling restrained the GM-CSF-mediated phosphorylation of HOXA10 and IRF8, which induce myeloid differentiation and monocyte/DC …
The roles of EZH2 in cancer and its inhibitors - PMC
The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair, …
EZH2 modulates mRNA splicing and exerts part of its oncogenic …
Jan 7, 2025 · In this study we investigate a potential crosstalk between EZH2 and mRNA splicing in CML. We describe how EZH2 modulates cellular splicing patterns through the …
EZH2: a novel target for cancer treatment - BioMed Central
Jul 28, 2020 · Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive complex 2 (PRC2) that can alter downstream target genes expression by …
SHP2 blockade enhances anti-tumor immunity via tumor cell
Jan 14, 2021 · In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein with allosteric SHP2 inhibitors promoted anti-tumor immunity, including …
Functional characterization of EZH2β reveals the increased …
Histone methyltransferase enhancer of zeste homologue 2 (EZH2) forms an obligate repressive complex with suppressor of zeste 12 and embryonic ectoderm development, which is thought, …
EZH2 harbors functional domains: WD-40 binding domain (WDB), domains I-II, two SWI3, ADA2, N-CoR and TFIIIB (SANT) domains, cysteine-rich CXC domain and evolutionarily conserved …
Enhancer of Zeste 2 (EZH2) is a bona fide oncogene that is among the most highly upregulated genes in CRPC relative to localized PCa (Varambally et al., 2002). EZH2 is a core subunit of …
Emerging role of EZH2 in solid tumor metastasis - PubMed
Both EZH2 protein and its catalytic function (H3K27me3) have been shown to promote solid tumor metastasis, although EZH2 functional inhibition has limited impact on primary tumor growth in …
SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell …
Boussiotis and colleagues show that the tyrosine phosphatase SHP-2 regulates the differentiation and antitumor function of monocytes downstream of the inhibitory PD-1 receptor.