Mar 12, 2021 · We confirm that loss of EZH2 induces resistance against cytarabine in the cell lines HEK293T and K562 as well as in a patient-derived xenograft model.

Sep 14, 2022 · EZH2 is mutated in nearly 25% of follicular lymphoma (FL) cases. Little is known about how EZH2 affects patients’ response to therapy.

May 11, 2020 · By impairing T cell help, mutant EZH2 prevents induction of proliferative MYC programs. Thus, EZH2 mutation fosters malignant transformation by epigenetically …

Nov 5, 2021 · Presence of EZH2 mutation has been linked to poor overall survival (OS) in patients (pts) with myelodysplastic syndromes (MDS) in studies (Bejar et al. 2015). However, potential …

The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and functional core subunit of the polycomb repressive complex 2 (PRC2), which is a key epigenetic regulator …

Jun 19, 2017 · Whole transcriptome analysis of EZH2 wild-type and mutant MDS/MPN patients showed distinct expression patterns , suggesting that the EZH2 mutational status has a global …

Béguelin et al. show that mutant EZH2 epigenetically reprograms germinal center B cells to alter their interactions with T follicular helper cells and follicular dendritic cells, facilitating malignant …

Colony assays indicated EZH2 mutations to be mostly early events in leukemogenesis and showed a complex mutational hierarchy. Gene expression data revealed a number of …

Aug 12, 2024 · We show that mutant-EZH2 elicits extensive effects on the epigenome of lymphomas, beyond alterations to H3K27 methylations, and is dominant over KMT2D …

EZH2 is a component of the polycomb repressive complex 2 (PRC2), which is a highly conserved histone methyltransferase that methylates lysine 27 of histone 3. EZH2 mutations are …