Symphony of epigenetic and metabolic regulation—interaction …
May 24, 2020 · In this review, we have summarized the correlation between EZH2 and cellular metabolic activity during tumor progression and drug treatment. Finally, as a promising target, …
Targeting EZH2 in Cancer: Mechanisms, Pathways, and …
Enhancer of zeste homolog 2 (EZH2) is a methyltransferase involved in cell cycle regulation, cell differentiation, and cell death and plays a role in modulating the immune response.
A distinct metabolic response characterizes sensitivity to EZH2 ...
Feb 12, 2021 · Specifically, EZH2i resulted in a miRNA-mediated downregulation of methionine cycling-associated genes in responsive cells. This induced metabolite accumulation and DNA …
S-Adenosyl-l-methionine-competitive inhibitors of the histone ...
Dec 22, 2014 · S-Adenosyl-l-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells
The roles of EZH2 in cancer and its inhibitors - PMC
EZH2 is involved in the cell cycle, DNA damage repair, cell differentiation, autophagy, apoptosis, and immunological modulation. The main function of EZH2 is to catalyze the methylation of H3 …
A druggable cascade links methionine metabolism to epigenomic …
Unexpectedly, unbiased bioinformatic screen identifies EZH2 as the most significant target downstream of the LAT1-methionine pathway, directly linking methionine metabolism to …
EZH2: a novel target for cancer treatment | Journal of Hematology ...
Jul 28, 2020 · This review discussed in detail about inhibitors of EZH2 methyltransferase activity, inhibitors that break PRC2’s structure, suppressing EZH2 through triggering EZH2 …
The roles of EZH2 in cancer and its inhibitors - PubMed
May 6, 2023 · EZH2 is involved in the cell cycle, DNA damage repair, cell differentiation, autophagy, apoptosis, and immunological modulation. The main function of EZH2 is to …
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2 ...
Dec 6, 2012 · EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2) and is involved in repressing gene expression through methylation of histone H3 on lysine 27 …
A distinct metabolic response characterizes sensitivity to EZH2 ...
Feb 12, 2021 · By coupling liquid chromatography-mass spectrometry with gene and miRNA expression profiling, we found that sensitivity to EZH2i correlated with distinct metabolic …