EZH2 is essential for development of mouse preimplantation …
Enhancer of zeste homologue 2 (Ezh2) is essential for the development of the early mouse preimplantation embryo. Loss of Ezh2 results in embryonic lethality in mice. Ezh2-deficient …
Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP …
Jan 27, 2014 · Here we show that EZH2 is a novel interactor and substrate of the SCF E3 ubiquitin ligase β-TrCP (FBXW1). β-TrCP ubiquitinates EZH2 and Jak2-mediated …
Ezh2 Antibody - Cell Signaling Technology
4 days ago · Polyclonal Antibody for studying EZH2. Validated for ChIP, IP, WB. Highly specific and rigorously validated in-house, Ezh2 Antibody (CST #4905) is ready to ship.
Posttranslational regulation of FOXA1 by Polycomb and …
A time-course cycloheximide (CHX) experiment revealed that FOXA1 protein half-lives were markedly decreased, from approximately 9 hours in control LNCaP cells to less than 2 hours in …
Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is …
Nov 5, 2019 · We aimed to elucidate the precise post-translational regulations of EZH2 and their role in cancer pathogenesis. Here, we show that SET and MYND domain containing 2 …
O‐GlcNAc regulates anti‐fibrotic genes in lung fibroblasts through EZH2 …
The lung fibroblasts lysates were subjected to immunoprecipitation with antibody against O‐GlcNAc, which specifically recognizes O‐GlcNAc. An antibody specific to EZH2 was used to …
USP7 stabilizes EZH2 and enhances cancer malignant progression
Jan 1, 2020 · To explore the potential of USP7 to modulate the stability of EZH2, the cycloheximide (CHX) chase assay was performed to detect the half-life of EZH2. In this …
A PRC2-independent function for EZH2 in regulating rRNA 2′-
Apr 1, 2021 · We demonstrate that EZH2 enhances rRNA 2′- O methylation via its direct interaction with FBL. Mechanistically, EZH2 strengthens the FBL–NOP56 interaction and …
EZH2 attenuates FOXA1 ubiquitination and degradation requiring …
(A) LNCaP cells were treated with EZH2 inhibitors at indicated doses for 7 days before WB analysis. (B and C) LNCaP cells were treated with 2 M EZH2 inhibitors for 96 hours and CHX …
E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte ...
Mar 26, 2021 · Neural precursor cell expressed developmentally downregulated 4‐like (NEDD4L) is a highly conserved HECT type E3 ligase that plays an important role in regulating …