H3K27me3-rich genomic regions can function as silencers to ... - Nature
Jan 29, 2021 · PcG domains are marked by H3K27me3, which is deposited by the catalytic component of PRC2 complex, mainly Enhancer of Zeste Homolog 2 (EZH2) and sometimes …
EZH2 noncanonically binds cMyc and p300 through a cryptic ...
Feb 24, 2022 · Here, we report that in acute leukaemias, EZH2 has additional noncanonical functions by binding cMyc at non-PRC2 targets and uses a hidden transactivation domain …
Genome-wide ChIP-seq analysis of EZH2-mediated H3K27me3 …
Feb 1, 2017 · Our results showed EZH2 to be highly overexpressed in astrocytic tumors with a significant positive correlation with grade. Interestingly, ChIP-seq mapping revealed distinct …
Integrated bioinformatics analysis of chromatin regulator EZH2 in ...
Enhancer of zeste homolog 2 (EZH2), a dynamic chromatin regulator in cancer, represents a potential therapeutic target showing early signs of promise in clinical trials. EZH2 ChIP …
Polycomb- and Methylation-Independent Roles of EZH2 as a …
Enhancer of Zeste 2 (EZH2) is the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), which catalyzes histone H3 lysine 27 trimethylation (H3K27me3) at target promoters …
EZH2 modulates mRNA splicing and exerts part of its oncogenic …
Jan 7, 2025 · The polycomb protein EZH2 is up-regulated in Chronic Myeloid Leukaemia (CML) and associated with transcriptional reprogramming. Here we tested whether EZH2 might also …
The EZH2- H3K27me3-DNMT1 complex orchestrates epigenetic ... - PubMed
Collectively, our results reveal crosstalk between H3K27me3 inhibition catalyzed by EZH2 and CpG island methylation mediated by DNMT1 within the wwc1 promoter, which synergistically …
To determine whether EZH2 is recruited to these exogenous DNA fragments, we performed EZH2 ChIP-qPCR using a forward primer that targets the plasmid backbone and a reverse primer …
Genome-wide ChIP-seq analysis of EZH2-mediated H3K27me3 target gene ...
Jan 5, 2017 · Our results showed EZH2 to be highly overexpressed in astrocytic tumors with a significant positive correlation with grade. Interestingly, ChIP-seq mapping revealed distinct …
EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of
May 11, 2022 · Here, we investigated the role of the EZH2-mediated H3K27me3 apposition in neuronal differentiation. We made use of a transgenic mouse model harboring Ezh2 …