EVI1 dysregulation: impact on biology and therapy of myeloid ...
Mar 22, 2021 · EVI1 is an oncogenic zinc-finger transcription factor whose overexpression contributes to disease progression and an aggressive phenotype, correlating with poor clinical …
MECOM - Wikipedia
EVI1 is a nuclear transcription factor involved in many signaling pathways for both coexpression and coactivation of cell cycle genes. The EVI1 gene is located in the human genome on …
Oncogene EVI1 drives acute myeloid leukemia via a targetable
May 15, 2024 · EVI1 encodes a nuclear protein containing two DNA binding zinc-finger domains, which is an essential transcriptional regulator that has important repressive functions (7, 8). In …
The EVI1 gene in myeloid leukemia - PubMed
EVI1 encodes a zinc finger protein inappropriately overexpressed by chromosomal rearrangements (in man) or by retroviral insertion (in the mouse). Both genes are rearranged …
EVI1 in Leukemia and Solid Tumors - PMC - PubMed Central (PMC)
Ecotropic viral integration site 1 (EVI1) is an oncogenic transcription factor that plays an important role in development and oncogenesis. EVI1 normally exists as a single gene, or as a longer …
High EVI1 levels predict adverse outcome in acute myeloid …
Apr 15, 2008 · We demonstrate in a cohort of 534 AML cases that high EVI1 expression, considering the various currently known EVI1 splice variants, is an independent predictor of …
EVI1-mediated Programming of Normal and Malignant …
Ecotropic viral integration site 1 (EVI1), encoded at the MECOM locus, is an oncogenic zinc finger transcription factor with diverse roles in normal and malignant cells, most extensively studied …
EVI1 triggers metabolic reprogramming associated with leukemogenesis ...
Deregulation of cellular metabolism, leading to development of leukemia, occurs through abnormally high expression of transcription factors such as MYC and Ecotropic Virus …
EVI1 is critical for the pathogenesis of a subset of MLL-AF9 ...
Jun 14, 2012 · Using the Evi1pos MLL-AF9 mouse leukemia model, we demonstrate increased sensitivity to chemotherapeutic agents on reduction of Evi1 expression. We conclude that …
EVI1 drives leukemogenesis through aberrant ERG activation
Feb 2, 2023 · To characterize gene regulatory functions of EVI1 and associated dependencies in AML, we developed experimentally tractable human and murine disease models, investigated …