The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

This review focuses on the mechanism of the nuclear ERK/MAPK signalling pathway in cancer development. Specifically, the basic components of the MAPK signalling pathway and its basic structure, function and ERK composition are summarized.

Jun 23, 2020 · In this Review, we discuss the current understanding of this important class of kinases. We begin with a brief overview of the structure, regulation, substrate recognition and subcellular...

This Special Issue covers recent advances in the molecular mechanisms and functions of MAPK-ERK signaling in different biological contexts. As the critical focal point of the Raf/MEK/ERK pathway signaling, ERK1 and ERK2 (referred to as ERK1/2) have essential roles throughout development and adulthood.

The Ras/Raf/MAPK (MEK)/ERK pathway is the most important signalling cascade among all MAPK signal transduction pathways, and plays a crucial role in the survival and development of tumour cells.

The central role played by the ERK/MAPK pathway downstream of RAS in human neoplasias is best exemplified in the context of melanoma skin cancer. Signaling through the MAPK pathway is crucial for the proliferation of melanocytes, the healthy pigment cells that give rise to melanoma.

The Ras/Raf/MAPK (MEK)/ERK pathway is the most important signalling cascade among all MAPK signal transduction pathways, and plays a crucial role in the survival and development of tumour cells.

The MAPK/ERK pathway is a highly conserved kinase cascade that regulates cellular phenotype changes by modifying gene expression, particularly in the central nervous system. It plays a crucial role in neuronal functioning by phosphorylating transcription factors and proteins involved in motor function and exocytosis.

Mar 1, 2002 · MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPK families have been...

Mar 20, 2025 · Explore the MAPK/ERK signaling cascade, its regulatory mechanisms, cellular roles, and detection methods in molecular biology research.