The results are the first to show that the pro- and anti-cancer progesterone metabolites also have marked selective (up or down) regulatory effects on ER levels in MCF-7 breast cancer cells.

Here we report that ERα regulates the cell cycle by suppressing p53/p21 and up-regulating proliferating cell nuclear antigen (PCNA) and proliferation-related Ki-67 antigen (Ki-67) to …

In the present study, the expression of estrogen receptor (ER)α and ERβ isoforms in ER-positive (MCF7, T-47D and ZR-75-1) and ER-negative (MDA-MB-231, SK-BR-3, MDA-MB-453 and …

To help resolve these issues, we compared cAMP mechanistic responses in MCF-7 cell lines selected for low (mER low) and high (mER high) expression of the membrane form of estrogen …

The current paper provides a broad description of the MCF-7 cell line, including the molecular profile, proliferation, migration, invasion, spheroid formation, its involvement in angiogenesis …

Mar 31, 2015 · MCF-7 as a Model of Response and Resistance to ER-Targeted Therapy. MCF-7 cells have served as a model for the study of estrogen response both in vitro and in vivo. The …

Jan 1, 2014 · To address this issue, we established several estrogen-deprivation-resistant (EDR) breast cancer cell lines from our unique MCF-7 cells, which had been stably transfected with …

Nov 27, 2013 · In this study, we show that ERα promotes cell proliferation in MCF–7 cells. Our results demonstrate that ERα promotes S–phase entry of MCF–7 cells and cell proliferation by …

2 days ago · Results: MCF-10A started to die at 42°C for 3 h while MDA-MB 231 and MCF-7 need a temperature of 38°C for 0.5 h; thus, they were identified as the threshold temperatures in …

Among many cell lines, the MCF-7 line has been widely used in in vitro breast cancer research worldwide for many years. It is positive for estrogen (ER), progesterone (PR), human …