Epac2 is a target of cAMP, a major second messenger in various cells. Epac2 is coded by the RAPGEF4 gene, and is expressed mainly in brain, neuroendocrine, and endocrine tissues. [8] …

Epac (exchange protein activated by 3’-5’-cyclic adenosine monophosphate [cAMP]) has been investigated functionally and pathophysiologically as a potential therapeutic target of various …

EPAC2 inhibition compromised proapoptotic caspase adaptor protein (PACAP)-triggered astrocytic differentiation of neural precursor cells devoid of neuronal differentiation. …

Apr 30, 2020 · Activation as well as over-secretion of EPAC2 triggers apoptosis in neurons and EPAC-triggered apoptosis was intermediated via the modulation of Bcl-2 interacting member …

Jan 10, 2016 · Epac2 is a potential therapeutic target for treatment of type 2 diabetes. Epac (exchange protein activated by cyclic-AMP) 2 is a direct target of 3′-5′-cyclic adenosine …

Epac1 (cAMP-GEF-1) and Epac2 (cAMP-GEF-II) are expressed in both mature and developing tissues. Recent studies have indicated that alterations in the cellular microenvironment are …

Jun 21, 2021 · Herein, we demonstrated that EPAC2 plays a dominant role in regulating HMPV, AdV, and RSV infections. Treatment with MAY0132, an EPAC2-specific inhibitor, suppressed …

EPAC2 is a multi-domain protein with a molecular weight of ~116 kDa, containing a regulatory as well as catalytic components. 4,26 NH 2 -terminal forms the regulatory segment while COOH …

Jan 10, 2016 · Epac2 is expressed mainly in brain, neuroendocrine and endocrine tissues, and is involved in diverse cellular functions in the tissues. In this review, we summarize the structure …

Dec 3, 2021 · Epac‐2 activation significantly suppressed nuclear factor (NF)‐κB/mitogen‐activated protein kinase (MAPK) signalling in vivo and in vitro. Epac‐2 may be a therapeutic target for …