p300 or CBP is required for insulin-stimulated glucose uptake …
Jan 11, 2022 · Here, we demonstrate that combined loss of the acetyltransferases E1A binding protein p300 (p300) and cAMP response element binding protein binding protein (CBP) in …
The P300 acetyltransferase inhibitor C646 promotes membrane ...
Inhibition of P300 acetyltransferase activity by C646 drastically increased tyrosine phosphorylation of the insulin receptor protein substrates (IRS1/2) without affecting the tyrosine …
The p300 and CBP Transcriptional Coactivators Are Required for β …
p300 (EP300) and CBP (CREBBP) are transcriptional coactivators with histone acetyltransferase activity. Various β-cell transcription factors can recruit p300/CBP, and thus the coactivators …
Frontiers | Identification of EP300 as a Key Gene Involved in ...
Aug 13, 2021 · EP300 encodes the protein p300, which functions as an acetyltransferase for histones and other proteins, thereby regulating transcriptional activity (Yao et al., 2018). This …
EP300 - Wikipedia
The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator …
Efficient and Simple Production of Insulin-Producing Cells from ...
Mar 10, 2014 · The peak response at the 100 µg/ml MPE used for investigation of EP300 and CREB1 gene expression. When stimulated with glucose, these cells synthesized and secreted …
Hyperinsulinism in an individual with an EP300 variant of …
The mechanism for hyperinsulinism in EP300 variant RSTS is not well understood. Wong et al. found that both CREBBP and EP300 are required for normal pancreatic islet cell development, …
Paradoxical activation of AMPK by glucose drives selective EP300 …
Jun 30, 2020 · Recent insights have revealed a key integrating role for the evolutionarily conserved lysine acetyl-transferases EP300 and the highly related CREB-binding protein …
Ep300 E1A binding protein p300 [ (house mouse)] - National …
Jan 4, 2025 · p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes. Long Non-Coding RNA NEAT1 Knockdown Alleviates Rheumatoid Arthritis by …
EP300 mutation is associated with tumor mutation burden and …
In summary, our study demonstrated that EP300 was frequently mutated in bladder cancer, and EP300 mutation was associated with higher TMB and indicated a better prognosis. …