The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A -associated cellular p300 transcriptional co-activator …

Mar 30, 2025 · EP300 (E1A Binding Protein P300) is a Protein Coding gene. Diseases associated with EP300 include Rubinstein-Taybi Syndrome 2 and Menke-Hennekam Syndrome 2. Among …

CREB-binding protein (CREBBP) and E1A-binding protein P300 (EP300) are two key acetyltransferases and transcriptional cofactors that regulate gene expression by regulating …

The EP300 gene provides instructions for making a protein called p300, which regulates the activity of many genes in tissues throughout the body. Learn about this gene and related …

Nov 5, 2024 · EP300/CBP inhibition causes cell cycle arrest and apoptosis in multiple myeloma (MM) models through concomitant suppression of interferon regulatory factor 4 (IRF4) and …

Feb 9, 2025 · EP300 promotes tumor stemness via epigenetic activation of CRISP3 leading to lobaplatin resistance in triple-negative breast cancer.

EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein . EP300 is a member of the histone acetyltransferase (HAT) family and regulates transcription …

EP300 promotes tumor stemness via epigenetic activation of CRISP3 leading to lobaplatin resistance in triple-negative breast cancer. P300 Participates in Ionizing Radiation-Mediated …

Nov 22, 2023 · CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which induces cell-cycle arrest and differentiation in hematologic malignancy model systems.

Recent studies have identified EP300, a histone acetyltransferase, as a crucial regulator of the epigenetic changes that contribute to fibrosis. In fact, EP300-mediated acetylation of histones …