Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa [5] and has 53 amino acid residues and three intramolecular disulfide bonds. [6] EGF was originally described as a secreted peptide found in the submaxillary glands of mice and in human urine.

ErbB-2 was named for its similarity to avian erythroblastosis oncogene B, ErbB; the oncogene later shown to code for epidermal growth factor receptor, EGFR. Molecular cloning of EGFR discovered that HER2, Neu, and ErbB-2 are all encoded by the same orthologs .

Epidermal growth factor (EGF) is a 53‐aminoacids polypeptide originally isolated from mouse salivary glands. EGF discovery was presided by its ability to stimulate epithelial growth and differentiation upon its injection to newborn mice 1, 2.

Here, we review the molecular mechanisms that regulate EGFR signal transduction, including the EGFR structure and its mutations, ligand binding and EGFR dimerization, as well as the signaling pathways that lead to G1 cell cycle progression.

EGF has been identified as a novel autocrine/paracrine magnesiotropic hormone that stimulates Mg 2+ reabsorption in the DCT via engagement of its receptor on the basolateral membrane of DCT cells and subsequent activation of the Mg 2+ channel TRPM6 in the apical surface .

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Sep 20, 2002 · In this study, the crystal structure of a 2:2 complex of human EGF and the EGFR extracellular region has been determined at 3.3 Å resolution. EGFR domains I–III are arranged in a C shape, and EGF is docked between domains I and III.

Mar 19, 2025 · Explore how EGF influences mammalian cell growth through receptor interactions, signaling pathways, and cross-talk with other growth factors. ... Raf phosphorylates MEK1/2, which in turn activates ERK1/2. Activated ERK translocates to the nucleus, phosphorylating transcription factors such as Elk-1 and c-Myc, promoting cell cycle progression. ...

Jan 1, 2018 · Epidermal growth factor (EGF) is a growth factor best known for its ability to stimulate cell growth and proliferation.

Nov 3, 2008 · EGF regulates Mg 2+ reabsorption through activation of renal TRPM6 channels. In the DCT, EGF precursors are targeted to the plasma membrane, and pro-EGF is released into the extracellular environment as EGF, presumably via ADAMs.