In a recent paper, Jung et al. 2 present compelling evidence that ancestral BPA exposure in mice drives ectopic long-range chromatin rearrangements between the Fto, Irx3 and Irx5 gene loci, which are maintained for up to six generations in sperm and are responsible for BPA-induced transgenerational inheritance of obesity.

Dec 20, 2017 · Fig. 6 shows the in situ UV–vis transmission spectra of FTO-ECD and Au/FTO-ECD under difference bias voltages. The light transmittance of both ECDs decreased with the increasing bias voltage, and became saturated at −0.8 V and −0.7 V, respectively.

Mar 7, 2025 · We find that among human tissues, FTOrs9939609-A most robustly affect human muscle progenitors’ proliferation, differentiation, senescence, thereby accelerating muscle developmental and...

In a recent paper, Jung et al.2 present compelling evidence that ancestral BPA exposure in mice drives ectopic long-range chromatin rearrangements between the Fto, Irx3 and Irx5 gene loci, which...

May 5, 2022 · Here, we show that FTO mediates m 6 A demethylation of long-interspersed element-1 (LINE1) RNA in mouse embryonic stem cells (mESCs), regulating LINE1 RNA abundance and the local chromatin state, which in turn modulates the transcription of LINE1-containing genes.

Mar 1, 2024 · In this work, an OPECT biosensor for the detection of fat mass and obesity-associated protein (FTO) was constructed, in which ZnSe/Bi 2 MoO 6 was chosen as the gate material, hm 6 ARNA (containing N 6-methyladenine RNA sequence) as the target molecule, and hydroquinone as the electron donor.

Sep 15, 2019 · Fluorine doped tin oxide (FTO) electrochemical immunosensor has been developed for rapid detection of urokinase type plasminogen activator receptor (uPAR) - a biomarker for cancer. uPAR is a GPI-anchored cell membrane receptor that shows increased expression in many types of human cancers which incl …

Jul 15, 2024 · In this study, an electrochemiluminescence (ECL) biosensor for the detection of demethylase FTO was developed based on DNAzyme-mediated CRISPR/Cas12a signal cascade amplification system and carboxylated carbon nitride nanosheets/phosphorus-doped nitrogen-vacancy modified carbon nitride nanosheets (C–CN/PCN V) heterojunction as the emitter.

Feb 15, 2023 · In a recent paper, Jung et al. 2 present compelling evidence that ancestral BPA exposure in mice drives ectopic long-range chromatin rearrangements between the Fto, Irx3 and Irx5 gene loci, which...

Apr 1, 2023 · Early-life exposure to EDCs: role in childhood obesity and neurodevelopment. Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of BPA-induced obesity. Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo.