Biochemical and functional assessment using both in vitro and in vivo models identified an unexpected, prominent role for E2F1 in regulation of redox metabolism after RB loss, driving …

Dec 8, 2015 · HPV expresses the viral oncogene E7 that binds to the retinoblastoma protein (RB1) in order to activate the E2F pathway. RB1 can mediate contradictory pathways—cell …

Apr 1, 2001 · In particular, it is now clear that the Rb/E2F pathway is critical in regulating the initiation of DNA replication. It is also clear that the control of the pathway is disrupted in …

In particular, it is now clear that the Rb/E2F pathway is critical in regulating the initiation of DNA replication. It is also clear that the control of the pathway is disrupted in virtually all human …

May 3, 2019 · Activator protein (E2F1, E2F2 and E2F3A) levels peak at the G1–S phase transition, and atypical repressor (E2F7 and E2F8) levels peak later in late S phase, whereas …

Biochemical and functional assessment using both in vitro and in vivo models identified an unexpected, prominent role for E2F1 in regulation of redox metabolism after RB loss, driving …

Jul 1, 2023 · Thus, it is clear that HPV stimulates E2F1-mediated transcription via the E7-Rb-E2F1 pathway (Fig. 3). Although uncommon, E2F1mutations have been reported in oral …

Jun 1, 2017 · HPV E7 was found to disrupt the pRB-related transcriptional repressor complex DREAM (D P, R B-like, E 2F4 a nd M uvB) 25, 26, 27. The DREAM protein complex consists …

HPV expresses the viral oncogene E7 that binds to the retinoblastoma protein (RB1) in order to activate the E2F pathway. RB1 can mediate contradictory pathways—cell growth and cell …

Recent findings in the Rb/E2F field are clarifying how this pathway regulates the transition from G 1 to S phase at the molecular level. Other emerging results show that this pathway also …