Aug 20, 2020 · Functional studies showed that E2F7 promoted cell proliferation, cell-cycle progression, cell metastasis and tumorigenicity abilities in vitro and in vivo. E2F7 promoted the transcription...

E2F7 promoted the transcription of EZH2 by binding to its promoter and increased H3K27me3 level. EZH2 recruited H3K27me3 to the promoter of PTEN and inhibited PTEN expression, and then activated the AKT/mTOR signalling pathway.

Jul 30, 2024 · By attaching to the promoter of EZH2 and raising H3K27me3, E2F7 aided in the transcription of EZH2. At the same time, PTEN expression was suppressed by EZH2's recruitment of H3K27me3 to its promoter, which was followed by activation of the AKT/mTOR signaling pathway .

By attaching to the EZH2 promoter, the transcription factor E2F7 increases H3K27Me3, decreases PTEN expression, and activates the Akt/mTOR signaling pathway [39, 40]. By activating TNFSF13B, EZH2 increases Akt phosphorylation, but when the level of the demethylase KDM2B is lowered, EZH2 inhibits the phosphorylation of PI3K and Akt [ 41 , 42 ].

Functional studies showed that E2F7 promoted cell proliferation, cell-cycle progression, cell metastasis and tumorigenicity abilities in vitro and in vivo. E2F7 promoted the transcription of EZH2...

Mechanically, E2F7 directly regulates the transcriptional activity of EZH2 via binding at the corresponding promoter area. Conclusions: E2Fs (except for E2F3 and E2F5) are highly expressed in HGG and indicate adverse outcome. E2F7 and E2F8 were identified as novel potential prognostic markers in HGG.

Functional studies showed that E2F7 promoted cell proliferation, cell-cycle progression, cell metastasis and tumorigenicity abilities in vitro and in vivo. E2F7 promoted the transcription of EZH2 by binding to its promoter and increased H3K27me3 level.

Jul 31, 2019 · We show that EZH2 mostly works as a transcriptional inducer in ACC, through cooperation with the transcription factor E2F1 and identify three positive targets involved in cell cycle regulation...

We found that E2F7 was positively correlated with EZH2, whereas E2F7 was negatively correlated with PTEN expression in clinical specimens (Fig. 6a).

Feb 1, 2022 · A recent experiment has revealed association between EZH2 and PTEN in GBM. In this case, E2F7 undergoes upregulation in GBM cells and enhances EZH2 expression by binding to its promoter. Then, H3K27me3 diminishes PTEN expression, resulting in PI3K/Akt signaling activation and subsequent increase in proliferation and migration of GBM cells [95 ...