Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene. [5][6] The protein encoded by this gene is a member of the E2F family of transcription factors.

Mar 28, 2025 · E2F4 (E2F Transcription Factor 4) is a Protein Coding gene. Diseases associated with E2F4 include Colorectal Cancer and Retinoblastoma. Among its related pathways are Defective binding of RB1 mutants to E2F1, (E2F2, E2F3) and G0 and Early G1.

E2F4 is a critical molecule in the RB/E2F pathway. Although E2F4 has been extensively studied as a repressor of cell cycle genes, here we present the novel perspective that E2F4 regulates diverse gene expression programs in cell fate decisions.

May 3, 2019 · In this Review, we discuss the activities of E2F proteins with an emphasis on the newest atypical E2F family members, the specific and redundant functions of E2F proteins, how misexpression of E2F...

Jul 3, 2019 · Here we show that E2F4 is important for the proliferation and the survival of mouse embryonic stem cells. In these cells, E2F4 acts in part as a transcriptional activator that promotes the...

Increased E2F4 levels and its translocation to the nucleus following genotoxic stress result in downregulation of mitotic genes. deregulated nuclear E2F4 expression induces apoptosis via multiple pathways in normal intestinal epithelial cells but not in colon cancer cells.

We used ChIP sequencing (ChIP-seq) to identify around 16 000 E2F4 binding sites which potentially regulate 7346 downstream target genes with wide-ranging functions in DNA repair, cell cycle regulation, apoptosis, and other processes.

In this study, we first explored the relationship between E2F4 expression and clinical phenotype in HNSCC, the role of E2F4 in the progression of HNSCC, especially as a prognostic factor of HNSCC, and its importance as a potential biomarker for the prognosis of HNSCC patients.

Here we review the canonical functions of E2F4 and discuss recent evidence expanding the role of this transcription factor, with a focus on cell fate decisions in tissue homeostasis and regeneration.

In the present study, we show that E2F4 enhances both the initiation and maintenance of nerve growth factor (NGF)-induced differentiation of PC12 cells into sympathetic-like neurons and that these effects do not involve changes in the regulation of cell growth.