Aug 21, 2015 · Ectopic overexpression of E2F1 promoted RRM2 transactivation while knockdown of E2F1 reduced the levels of RRM2 mRNA and protein. To further investigate the roles of RRM2 which was activated by E2F1 in CRC, CCK-8 assay …

An important transcriptional target of E2F1 which could contribute to DNA replication stress is ribonucleotide reductase member 2 (RRM2) (DeGregori et al., 1995; Chabes et al., 2004). RRM2 is the regulatory subunit of the essential enzyme ribonucleotide reductase (RNR).

Aug 21, 2015 · Understanding the role of E2F1 in activating RRM2 transcription will help to explain the relationship between E2F1 and RRM2 in CRC and provide a novel predictive marker for diagnosis and prognosis of the disease.

Jun 20, 2019 · E2F1, E2F2, and E2F3A, the three activators of the E2F family of transcription factors, are key regulators of the G1/S transition, promoting transcription of hundreds of genes critical for cell-cycle progression.

Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor. E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma.

Jan 1, 2024 · Regulation of RRM2 transcription by E2F1 and E2F4. Pocket proteins including Rb, p107, and p130 regulate the activation of E2Fs.

Jul 31, 2019 · We show that EZH2 mostly works as a transcriptional inducer in ACC, through cooperation with the transcription factor E2F1 and identify three positive targets involved in cell cycle regulation...

Our study highlights the role of ATM/Rb/E2F1 pathway in controlling cell cycle arrest and apoptosis in response to RRM2 inhibition-induced DNA damage. This provides insight into the therapeutic benefits of COH29 and suggests targeting this pathway as a …

Mar 28, 2018 · E2F1 promote CRC migration, invasion, and metastasis by controlling RRM2 transactivation. Fang et al. validated that both E2F1 and RRM2 were elevated in most CRC tissues compared to normal tissues. Protein expression levels of E2F1 and RRM2 were comparable and positively correlated with tumor stage and lymph node metastasis (LNM).

Mar 1, 2019 · The combination treatment markedly attenuated the deoxyribonucleoside triphosphate (dNTP) pools by downregulating the mRNA expression of RRM1 and RRM2 through E2F1. The overexpression of E2F1 or supplementation of dNTP rescued the anti-proliferation activity of the everolimus-SCH772984 combination.